loading...| Preferred Name | Finasteride | |
| Synonyms |
|
|
| Definitions |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1099 |
|
| ALT_DEFINITION |
A drug used to reduce the amount of male hormone (testosterone) produced by the body. |
|
| CAS_Registry |
98319-26-7 |
|
| CHEBI_ID |
CHEBI:5062 |
|
| Chemical_Formula |
C23H36N2O2 |
|
| code |
C1099 |
|
| Contributing_Source |
CTRP FDA |
|
| definition |
A synthetic 4-azasteroid compound. Finasteride competitively binds to and inhibits steroid type II 5-alpha-reductase in the prostate gland, liver, and skin, thereby interfering with the enzymatic conversion of testosterone to 5-dihydrotestosterone (DHT) and reducing serum DHT levels. The reduction in serum DHT levels results in diminished stimulation of androgen receptors in the nuclei of prostate cells and, so, diminished prostate cell proliferation. |
|
| Display_Name |
Finasteride |
|
| FDA_UNII_Code |
57GNO57U7G |
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Finasteride |
|
| Legacy Concept Name |
Finasteride |
|
| NCI_Drug_Dictionary_ID |
41096 |
|
| PDQ_Closed_Trial_Search_ID |
41096 |
|
| PDQ_Open_Trial_Search_ID |
41096 |
|
| Preferred_Name |
Finasteride |
|
| prefixIRI |
NCIT:C1099 |
|
| prefLabel |
Finasteride |
|
| Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
| UMLS_CUI |
C0060389 |
|
| subClassOf |