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Biological and Environmental Research Ontology
| Preferred Name | Cefepime Hydrochloride | |
| Synonyms |
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|
| Definitions |
The hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1041 |
|
| Accepted_Therapeutic_Use_For |
Upper respiratory tract and urinary tract infections; febrile neutropenic conditions
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|
| CAS_Registry |
123171-59-5
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|
| CHEBI_ID |
CHEBI:31368
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|
| Chemical_Formula |
C19H24N6O5S2.2ClH.H2O
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|
| code |
C1041
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|
| Contributing_Source |
CTRP FDA
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|
| definition |
The hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins.
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|
| Display_Name |
Cefepime Hydrochloride
|
|
| FDA_UNII_Code |
I8X1O0607P
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| Has_Free_Acid_Or_Base_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Cefepime Hydrochloride
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|
| Legacy Concept Name |
Cefepime
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|
| NCI_Drug_Dictionary_ID |
38350
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|
| PDQ_Closed_Trial_Search_ID |
38350
|
|
| PDQ_Open_Trial_Search_ID |
38350
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|
| Preferred_Name |
Cefepime Hydrochloride
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|
| prefixIRI |
NCIT:C1041
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|
| prefLabel |
Cefepime Hydrochloride
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|
| Semantic_Type |
Organic Chemical Pharmacologic Substance Antibiotic
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|
| UMLS_CUI |
C0771284
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| subClassOf |
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