Biological and Environmental Research Ontology

Last uploaded: December 23, 2022
Jump to:
Preferred Name

Pegfilgrastim Biosimilar LA-EP2006
Synonyms
Definitions

A biosimilar of pegfilgrastim, a long-acting pegylated form of recombinant human granulocyte colony-stimulating factor (G-CSF) filgrastim, with hematopoietic activity. In a similar manner to G-CSF, pegfilgrastim biosimilar LA-EP2006 binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Therefore, this agent may prevent the incidence and shorten the duration of chemotherapy-induced neutropenia. Conjugation of the cytokine with a branched polyethylene glycol molecule significantly increases this agent's therapeutic half-life compared to filgrastim.
ID

http://purl.obolibrary.org/obo/NCIT_C104005
code

C104005
definition

A biosimilar of pegfilgrastim, a long-acting pegylated form of recombinant human granulocyte colony-stimulating factor (G-CSF) filgrastim, with hematopoietic activity. In a similar manner to G-CSF, pegfilgrastim biosimilar LA-EP2006 binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Therefore, this agent may prevent the incidence and shorten the duration of chemotherapy-induced neutropenia. Conjugation of the cytokine with a branched polyethylene glycol molecule significantly increases this agent's therapeutic half-life compared to filgrastim.
in_subset

http://purl.obolibrary.org/obo/NCIT_C176424
label

Pegfilgrastim Biosimilar LA-EP2006
NCI_Drug_Dictionary_ID

724518
NCI_META_CUI

CL433964
PDQ_Closed_Trial_Search_ID

724518
PDQ_Open_Trial_Search_ID

724518
Preferred_Name

Pegfilgrastim Biosimilar LA-EP2006
prefixIRI

NCIT:C104005
prefLabel

Pegfilgrastim Biosimilar LA-EP2006
Semantic_Type

Amino Acid, Peptide, or Protein

Pharmacologic Substance
subClassOf

http://purl.obolibrary.org/obo/NCIT_C387
Add comment
Add proposal
Delete Subject Author Type Created
No notes to display