loading...| Preferred Name |
Piritrexim |
|
| Synonyms |
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|
| Definitions |
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04) |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C1031 |
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| ALT_DEFINITION |
A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called folate antagonists. |
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| CAS_Registry |
72732-56-0 |
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| Chemical_Formula |
C17H19N5O2 |
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| code |
C1031 |
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| Contributing_Source |
FDA |
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| definition |
A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04) |
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| FDA_UNII_Code |
MK2A783ZUT |
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| Has_Salt_Form | ||
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C177537 http://purl.obolibrary.org/obo/NCIT_C176424 http://purl.obolibrary.org/obo/NCIT_C128784 |
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| Is_Value_For_GDC_Property | ||
| label |
Piritrexim |
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| Legacy Concept Name |
Piritrexim |
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| Maps_To |
Piritrexim |
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| NCI_Drug_Dictionary_ID |
40070 |
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| NSC Number |
351521 |
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| PDQ_Closed_Trial_Search_ID |
40070 |
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| PDQ_Open_Trial_Search_ID |
40070 |
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| Preferred_Name |
Piritrexim |
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| prefixIRI |
NCIT:C1031 |
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| prefLabel |
Piritrexim |
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| Semantic_Type |
Organic Chemical Pharmacologic Substance |
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| UMLS_CUI |
C0054332 |
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| subClassOf |