Preferred Name |
Lipopolysaccharide |
|
Synonyms |
|
|
Definitions |
An endotoxin and biologically active component of the Gram-negative bacterial cell wall that is a Toll-like receptor 4 (TLR4) agonist with potential immunostimulatory activity. Upon internalization, lipopolysaccharide (LPS) activates TLR4 which in turn activates the NFkappaB pathway, in addition to mitogen-activated protein kinases signaling pathways. This leads to the release of proinflammatory cytokines and stimulates an innate immune response against vaccine antigens. |
|
ID |
http://purl.obolibrary.org/obo/NCIT_C101788 |
|
CHEBI_ID |
CHEBI:16412 |
|
code |
C101788 |
|
definition |
An endotoxin and biologically active component of the Gram-negative bacterial cell wall that is a Toll-like receptor 4 (TLR4) agonist with potential immunostimulatory activity. Upon internalization, lipopolysaccharide (LPS) activates TLR4 which in turn activates the NFkappaB pathway, in addition to mitogen-activated protein kinases signaling pathways. This leads to the release of proinflammatory cytokines and stimulates an innate immune response against vaccine antigens. |
|
in_subset | ||
label |
Lipopolysaccharide |
|
NCI_Drug_Dictionary_ID |
732862 |
|
PDQ_Closed_Trial_Search_ID |
732862 |
|
PDQ_Open_Trial_Search_ID |
732862 |
|
Preferred_Name |
Lipopolysaccharide |
|
prefixIRI |
NCIT:C101788 |
|
prefLabel |
Lipopolysaccharide |
|
Semantic_Type |
Organic Chemical Pharmacologic Substance |
|
UMLS_CUI |
C0023810 |
|
subClassOf |