Link to this page
Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
Jump to:
| Preferred Name | Sofosbuvir | |
| Synonyms |
|
|
| Definitions |
An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome. |
|
| ID |
http://purl.obolibrary.org/obo/NCIT_C101263 |
|
| CAS_Registry |
1190307-88-0
|
|
| Chemical_Formula |
C22H29FN3O9P
|
|
| code |
C101263
|
|
| Contributing_Source |
CTRP FDA
|
|
| definition |
An orally available nucleotide prodrug and a hepatitis C virus (HCV) NS5B polymerase inhibitor with potential HCV inhibiting activity. Upon oral administration, sofosbuvir is metabolized to 2'-deoxy-2'-alpha-fluoro-beta-C-methyluridine-5'-monophosphate, which is then converted into the active triphosphate nucleotide that inhibits the NS5B polymerase, thereby preventing viral replication. The HCV NS5B protein, an RNA-dependent RNA polymerase, is essential for the replication of the viral HCV RNA genome.
|
|
| Display_Name |
Sofosbuvir
|
|
| FDA_UNII_Code |
WJ6CA3ZU8B
|
|
| in_subset |
http://purl.obolibrary.org/obo/NCIT_C63923 http://purl.obolibrary.org/obo/NCIT_C173383 http://purl.obolibrary.org/obo/NCIT_C173381 http://purl.obolibrary.org/obo/NCIT_C176424 |
|
| label |
Sofosbuvir
|
|
| NCI_Drug_Dictionary_ID |
729636
|
|
| PDQ_Closed_Trial_Search_ID |
729636
|
|
| PDQ_Open_Trial_Search_ID |
729636
|
|
| Preferred_Name |
Sofosbuvir
|
|
| prefixIRI |
NCIT:C101263
|
|
| prefLabel |
Sofosbuvir
|
|
| PubMedID_Primary_Reference |
20845908
|
|
| Semantic_Type |
Pharmacologic Substance
|
|
| UMLS_CUI |
C2976303
|
|
| subClassOf |
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |
Create mapping