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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | trichlormethiazide | |
| Synonyms |
trichlormethiazidum hydrotrichlorothiazide trichlormethiazide triclormetiazida 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide |
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| Definitions |
A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension. |
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| ID |
http://purl.obolibrary.org/obo/CHEBI_9683 |
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| alternative term |
trichlormethiazidum hydrotrichlorothiazide trichlormethiazide triclormetiazida 6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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| bearer of | ||
| charge |
0
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| database_cross_reference |
PMID:21605415 PMID:25938807 DrugBank:DB01021 KEGG:C07767 LINCS:LSM-4383 Drug_Central:2733 KEGG:D00658 PMID:25692026 PMID:24678944 PMID:28166217 Wikipedia:Trichlormethiazide PMID:29438107 PMID:28089902 CAS:133-67-5
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|
| definition |
A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.
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|
| formula |
C8H8Cl3N3O4S2
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|
| has_exact_synonym |
6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
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|
| has_obo_namespace |
chebi_ontology
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|
| has_related_synonym |
trichlormethiazidum hydrotrichlorothiazide trichlormethiazide triclormetiazida
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|
| id |
CHEBI:9683
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| in_subset | ||
| inchi |
InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)
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|
| inchikey |
LMJSLTNSBFUCMU-UHFFFAOYSA-N
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|
| label |
trichlormethiazide
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|
| mass |
380.658
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|
| monoisotopicmass |
378.90218
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|
| notation |
CHEBI:9683
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| prefLabel |
trichlormethiazide
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| RO_0000087 | ||
| smiles |
C12=C(NC(C(Cl)Cl)NS1(=O)=O)C=C(Cl)C(=C2)S(N)(=O)=O
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| subClassOf |
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