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Biological and Environmental Research Ontology
| Preferred Name | huperzine A | |
| Synonyms |
(-)-huperazine A huperzine-A (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one (-)-selagine Hup A HupA hupzine A kimpukan A selagine (5R,9R,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one |
|
| Definitions |
A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_78330 |
|
| alternative term |
(-)-huperazine A huperzine-A (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one (-)-selagine Hup A HupA hupzine A kimpukan A selagine (5R,9R,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
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|
| bearer of |
http://purl.obolibrary.org/obo/CHEBI_66980 http://purl.obolibrary.org/obo/CHEBI_76924 |
|
| charge |
0
|
|
| database_cross_reference |
HMDB:HMDB0242654 PMID:31990212 PMID:32970179 PMID:34306441 PMID:31922239 PMID:33252842 PMID:31305343 PMID:33278032 PMID:33675928 Chemspider:16736021 PMID:33504676 PMID:32708929 PMID:23306162 PMID:33708959 CAS:102518-79-6 PMID:32052235 Wikipedia:Huperzine_A PMID:12895686 PMID:33930191 Reaxys:3592896 PMID:33891962 AGR:IND606941294 PMID:32729341 PMID:34198639 PMID:34368579 PMID:32869005 PMID:24299147 PMID:34363318 PMID:34419561 PMID:24332448 PMID:34072855 PMID:32970952 PMID:24129696 PMID:24639880 DrugBank:DB04864 PMID:33851462 PMID:32576772 PMID:33567664 PMID:24190328 KNApSAcK:C00028361
|
|
| definition |
A sesquiterpene alkaloid isolated from a club moss Huperzia serrata that has been shown to exhibit neuroprotective activity. It is also an effective inhibitor of acetylcholinesterase and has attracted interest as a therapeutic candidate for Alzheimer's disease.
|
|
| formula |
C15H18N2O
|
|
| has_exact_synonym |
(5R,9R,11E)-5-amino-11-ethylidene-7-methyl-5,6,9,10-tetrahydro-5,9-methanocycloocta[b]pyridin-2(1H)-one
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
(-)-huperazine A huperzine-A (5R,9R,11E)-5-amino-11-ethylidene-5,6,9,10-tetrahydro-7-methyl-5,9-methanocycloocta[b]pyridin-2(1H)-one (-)-selagine Hup A HupA hupzine A kimpukan A selagine
|
|
| id |
CHEBI:78330
|
|
| in_subset | ||
| inchi |
InChI=1S/C15H18N2O/c1-3-11-10-6-9(2)8-15(11,16)12-4-5-14(18)17-13(12)7-10/h3-6,10H,7-8,16H2,1-2H3,(H,17,18)/b11-3+/t10-,15+/m0/s1
|
|
| inchikey |
ZRJBHWIHUMBLCN-YQEJDHNASA-N
|
|
| is_conjugate_base_of | ||
| label |
huperzine A
|
|
| mass |
242.31620
|
|
| monoisotopicmass |
242.14191
|
|
| notation |
CHEBI:78330
|
|
| prefLabel |
huperzine A
|
|
| RO_0000087 |
http://purl.obolibrary.org/obo/CHEBI_66980 http://purl.obolibrary.org/obo/CHEBI_76924 |
|
| smiles |
C\C=C1/[C@@H]2Cc3[nH]c(=O)ccc3[C@@]1(N)CC(C)=C2
|
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_38183 http://purl.obolibrary.org/obo/CHEBI_26979 |
| Delete | Subject | Author | Type | Created |
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