Preferred Name

tafluprost
Synonyms

Zioptan

tafluprost

isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate

Definitions

A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

ID

http://purl.obolibrary.org/obo/CHEBI_66899

alternative term

Zioptan

tafluprost

isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate

bearer of

http://purl.obolibrary.org/obo/CHEBI_66900

charge

0

database_cross_reference

PMID:22654492

PMID:22399693

PMID:22499235

PMID:22606063

Patent:EP1825855

PMID:22275814

PMID:22690824

Drug_Central:4229

PMID:22669351

PMID:22310086

PMID:21423041

PMID:22049909

Reaxys:9668502

KEGG:D06274

Wikipedia:Tafluprost

PMID:22583577

PMID:22107041

PMID:21491995

PMID:22695966

CAS:209860-87-7

definition

A prostaglandin Falpha that is prostaglandin F2alpha in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

formula

C25H34F2O5

has_exact_synonym

isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate

has_functional_parent

http://purl.obolibrary.org/obo/CHEBI_15553

has_obo_namespace

chebi_ontology

has_related_synonym

Zioptan

tafluprost

id

CHEBI:66899

in_subset

http://purl.obolibrary.org/obo/chebi#3_STAR

inchi

InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1

inchikey

WSNODXPBBALQOF-VEJSHDCNSA-N

label

tafluprost

mass

452.53130

monoisotopicmass

452.23743

notation

CHEBI:66899

prefLabel

tafluprost

RO_0000087

http://purl.obolibrary.org/obo/CHEBI_66900

smiles

CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(F)(F)COc1ccccc1

subClassOf

http://purl.obolibrary.org/obo/CHEBI_37143

http://purl.obolibrary.org/obo/CHEBI_35725

http://purl.obolibrary.org/obo/CHEBI_36066

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