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Biological and Environmental Research Ontology
Last uploaded:
December 23, 2022
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| Preferred Name | betahistine | |
| Synonyms |
2-(beta-methylaminoethyl)pyridine N-methyl-2-(2-pyridinyl)ethanamine betahistine betahistina N-methyl-2-pyridineethanamine [2-(2-pyridyl)ethyl]methylamine 2-[2-(methylamino)ethyl]pyridine betahistinum N-methyl-2-pyridin-2-ylethanamine |
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| Definitions |
An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_35677 |
|
| alternative term |
2-(beta-methylaminoethyl)pyridine N-methyl-2-(2-pyridinyl)ethanamine betahistine betahistina N-methyl-2-pyridineethanamine [2-(2-pyridyl)ethyl]methylamine 2-[2-(methylamino)ethyl]pyridine betahistinum N-methyl-2-pyridin-2-ylethanamine
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| bearer of | ||
| charge |
0
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| database_cross_reference |
PMID:20530654 DrugBank:DB06698 Reaxys:112294 Drug_Central:346 KEGG:D07522 PMID:7589314 HMDB:HMDB0015644 CAS:5638-76-6 LINCS:LSM-4044 Beilstein:112294 Wikipedia:Betahistine PMID:22365373 PMID:22745706
|
|
| definition |
An aminoalkylpyridine that is pyridine substituted by a 2-(methylamino)ethyl group at position 2. It acts as a histamine agonist and a vasodilator, and is thought to improve the microcirculation of the labyrinth, resulting in reduced endolymphatic pressure. It is used (generally as the hydrochloride or mesylate salt) to reduce the symptoms of vertigo, tinnitus, and hearing loss associated with Meniere's disease.
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|
| formula |
C8H12N2
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|
| has_exact_synonym |
N-methyl-2-pyridin-2-ylethanamine
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|
| has_obo_namespace |
chebi_ontology
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| has_related_synonym |
2-(beta-methylaminoethyl)pyridine N-methyl-2-(2-pyridinyl)ethanamine betahistine betahistina N-methyl-2-pyridineethanamine [2-(2-pyridyl)ethyl]methylamine 2-[2-(methylamino)ethyl]pyridine betahistinum
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|
| id |
CHEBI:35677
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|
| in_subset | ||
| inchi |
InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
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|
| inchikey |
UUQMNUMQCIQDMZ-UHFFFAOYSA-N
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|
| label |
betahistine
|
|
| mass |
136.19430
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|
| monoisotopicmass |
136.10005
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|
| notation |
CHEBI:35677
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|
| prefLabel |
betahistine
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|
| RO_0000087 | ||
| smiles |
CNCCc1ccccn1
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| subClassOf |
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