Preferred Name |
butenafine |
|
Synonyms |
4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine (4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine butenafinum butenafina butenafine 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine Butenafine |
|
Definitions |
Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections. |
|
ID |
http://purl.obolibrary.org/obo/CHEBI_3238 |
|
alternative term |
4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine (4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine butenafinum butenafina butenafine 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine Butenafine |
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bearer of | ||
charge |
0 |
|
database_cross_reference |
PMID:17371821 CAS:101828-21-1 LINCS:LSM-5956 PMID:8340915 Beilstein:6334654 KEGG:C08067 DrugBank:DB01091 Patent:US5021458 Drug_Central:444 KEGG:D07596 Wikipedia:Butenafine Patent:EP164697 |
|
definition |
Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections. |
|
formula |
C23H27N |
|
has_alternative_id |
CHEBI:205442 |
|
has_exact_synonym |
1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine Butenafine |
|
has_obo_namespace |
chebi_ontology |
|
has_related_synonym |
4-tert-butylbenzyl(methyl)(1-naphthalenemethyl)amine (4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine (4-tert-Butyl-benzyl)-methyl-naphthalen-1-ylmethyl-amine N-(p-tert-butylbenzyl)-N-methyl-1-naphthalenemethylamine butenafinum butenafina butenafine |
|
id |
CHEBI:3238 |
|
in_subset | ||
inchi |
InChI=1S/C23H27N/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20/h5-15H,16-17H2,1-4H3 |
|
inchikey |
ABJKWBDEJIDSJZ-UHFFFAOYSA-N |
|
label |
butenafine |
|
mass |
317.46720 |
|
monoisotopicmass |
317.21435 |
|
notation |
CHEBI:3238 |
|
prefLabel |
butenafine |
|
RO_0000087 | ||
smiles |
CN(Cc1ccc(cc1)C(C)(C)C)Cc1cccc2ccccc12 |
|
subClassOf |