Antibiotic Resistance Ontology

Last uploaded: December 18, 2024
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Preferred Name

betaxolol
Synonyms
Definitions

Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and angina, with a 50% inhibitory concentration (IC50) of 19.3 plus or minus 0.9 uM significantly inhibiting the hydrolytic activity of the NDM-1 enzyme and may represent a potential NDM-1 enzyme inhibitor. BET combined with meropenem (MEM) showed bactericidal synergism in vitro. BET inhibited NDM-1 by competitively binding to it and that it can be developed in combination with MEM as a new therapy.
ID

http://purl.obolibrary.org/obo/ARO_3007750
database_cross_reference

PubChem:2369

ChEMBL:CHEMBL423

CAS:63659-18-7

ChEBI:3082
definition

Betaxolol is a selective beta1 receptor blocker used in the treatment of hypertension and angina, with a 50% inhibitory concentration (IC50) of 19.3 plus or minus 0.9 uM significantly inhibiting the hydrolytic activity of the NDM-1 enzyme and may represent a potential NDM-1 enzyme inhibitor. BET combined with meropenem (MEM) showed bactericidal synergism in vitro. BET inhibited NDM-1 by competitively binding to it and that it can be developed in combination with MEM as a new therapy.
has_obo_namespace

antibiotic_resistance
id

ARO:3007750
label

betaxolol
notation

ARO:3007750
prefLabel

betaxolol
subClassOf

http://purl.obolibrary.org/obo/ARO_3007136
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Mapping To Ontology Source
http://sbmi.uth.tmc.edu/ontology/ochv#1837 OCHV LOOM
http://stirdf.jst.go.jp/id/200907081673812260 IOBC LOOM
https://github.com/sap218/ocimido/blob/master/ontology/ocimido.owl#OCIMIDO_00567 OCIMIDO LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D015784 RH-MESH LOOM
http://www.co-ode.org/ontologies/galen#Betaxolol GALEN LOOM
http://evs.nci.nih.gov/ftp1/NDF-RT/NDF-RT.owl#N0000147726 ODAE LOOM
http://purl.bioontology.org/ontology/LNC/LP70622-3 LOINC LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000147726 NDFRT LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.092.063.624.698.077 RH-MESH LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.755.624.698.077 RH-MESH LOOM
http://www.drugbank.ca/drugs/DB00195 FTC LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0005320 OCHV LOOM
http://purl.obolibrary.org/obo/MESH_D015784 BERO LOOM
http://purl.obolibrary.org/obo/NCIT_C61652 BERO LOOM
http://purl.bioontology.org/ontology/ATC/S01ED02 ATC LOOM
https://go.drugbank.com/drugs/DB00195 MDM LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C61652 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/409276006 SNOMEDCT LOOM
http://purl.jp/bio/4/id/200906067467940507 IOBC LOOM
http://purl.bioontology.org/ontology/MESH/D015784 MESH LOOM
http://www.phoc.org.cn/pmo/class/PMO_00015691 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/RXNORM/1520 NLMVS LOOM
http://purl.bioontology.org/ontology/RXNORM/1520 RXNORM LOOM
http://purl.bioontology.org/ontology/ATC/C07AB05 ATC LOOM
http://purl.obolibrary.org/obo/OMIT_0016424 OMIT LOOM
http://purl.obolibrary.org/obo/CHEBI_3082 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_3082 DINTO LOOM
http://purl.obolibrary.org/obo/CHEBI_3082 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_3082 DDSS LOOM
http://purl.obolibrary.org/obo/CHEBI_3082 CHEBI LOOM
http://purl.obolibrary.org/obo/CHEBI_3082 BIOMODELS LOOM
http://purl.obolibrary.org/obo/CHEBI_3082 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_3082 ODNAE LOOM
http://purl.bioontology.org/ontology/RCD/x01C0 RCD LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D02.033.100.624.698.077 RH-MESH LOOM
http://purl.bioontology.org/ontology/VANDF/4019633 VANDF LOOM