loading...| Preferred Name |
chenodeoxycholic acid |
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| Synonyms |
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| Definitions |
A cholic acid derivative of the traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, and this synergistic killing was effective against diverse methicillin-resistant S. aureus (MRSA) variants. Mechanistically, chenodeoxycholic acid increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates reactive oxygen species (ROS) generation by inhibiting superoxide dismutase activity. |
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| ID |
http://purl.obolibrary.org/obo/ARO_3007538 |
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| database_cross_reference |
pubchem.compound:10133 |
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| definition |
A cholic acid derivative of the traditional Chinese medicine (TCM) Tanreqing (TRQ), synergizes with amikacin against Staphylococcus aureus in vitro, and this synergistic killing was effective against diverse methicillin-resistant S. aureus (MRSA) variants. Mechanistically, chenodeoxycholic acid increases the uptake of aminoglycosides in a proton motive force-dependent manner by dissipating the chemical potential and potentiates reactive oxygen species (ROS) generation by inhibiting superoxide dismutase activity. |
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| has_obo_namespace |
antibiotic_resistance |
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| id |
ARO:3007538 |
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| label |
chenodeoxycholic acid |
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| notation |
ARO:3007538 |
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| prefLabel |
chenodeoxycholic acid |
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| subClassOf |