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Antibiotic Resistance Ontology
Last uploaded:
December 18, 2024
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| Preferred Name | cefoxitin | |
| Synonyms |
mefoxin Mefoxitin FOX |
|
| Definitions |
Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases. |
|
| ID |
http://purl.obolibrary.org/obo/ARO_0000008 |
|
| database_cross_reference |
PubChem:441199 ChEMBL:CHEMBL996 ChEBI:209807 CAS:35607-66-0
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|
| definition |
Cefoxitin is a cephamycin antibiotic often grouped with the second generation cephalosporins. Cefoxitin is bactericidal and acts by inhibiting the synthesis of the peptidoglycan layer of bacterial cell walls. The peptidoglycan layer is important for cell wall structural integrity, especially in Gram-positive organisms. Cefoxitin's 7-alpha-methoxy group and 3' leaving group make it a poor substrate for most beta-lactamases.
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|
| has_exact_synonym |
mefoxin Mefoxitin FOX
|
|
| has_obo_namespace |
antibiotic_resistance
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|
| id |
ARO:0000008
|
|
| label |
cefoxitin
|
|
| notation |
ARO:0000008
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|
| prefLabel |
cefoxitin
|
|
| subClassOf |
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