Are part of the EMERGE Medication Adherence Guide (Item 6a) [1] Grounded, A. R. G. E. (2018). ESPACOMP Medication Adherence Reporting Guideline (EMERGE). Ann Intern Med, 169, 30-35. These are direct methods [1,3] that measure drug intake. Some of them are more conclusive than others, since there are drugs whose concentration of metabolites can be detected in blood even long after the medication has been interrupted or simply the difference in concentrations of metabolites between individuals can become very noticeable, even though the same dose has been administered in each of them [1]. In addition, some drugs may interfere with others and hide the true concentration in the patient [1]. The existence of the "white coat" effect [1,2] should also be taken into account, which is defined as an increase in the level of adherence of the patient on the dates close to the day of the clinical visit. This would cause the medical test to evaluate the concentration of metabolites to reflect a different level of medication to that which corresponds to the dose that the patient is usually administered in the interstage between clinical visits [1]. [1] Lam, W. Y., & Fresco, P. (2015). Medication Adherence Measures: An Overview. BioMed Research International. e217047. https://doi.org/10.1155/2015/217047 [2]Manuscript, A., Blood, W., & Count, C. (2009). NIH Public Access, 49(18), 1841–1850. https://doi.org/10.1016/j.jacc.2007.01.076.White. [3] Lee, C. S., Tan, J. H. M., Sankari, U., Koh, Y. L. E., & Tan, N. C. (2017). Assessing oral medication adherence among patients with type 2 diabetes mellitus treated with polytherapy in a developed Asian community: a cross-sectional study. BMJ Open, 7(9), e016317. https://doi.org/10.1136/bmjopen-2017-016317 12893009 | Biological |

http://www.semanticweb.org/parracarlos/ontologies/2019/3/untitled-ontology-31#Biological

Are part of the EMERGE Medication Adherence Guide (Item 6a) [1] Grounded, A. R. G. E. (2018). ESPACOMP Medication Adherence Reporting Guideline (EMERGE). Ann Intern Med, 169, 30-35.

These are direct methods [1,3] that measure drug intake. Some of them are more conclusive than others, since there are drugs whose concentration of metabolites can be detected in blood even long after the medication has been interrupted or simply the difference in concentrations of metabolites between individuals can become very noticeable, even though the same dose has been administered in each of them [1]. In addition, some drugs may interfere with others and hide the true concentration in the patient [1]. The existence of the "white coat" effect [1,2] should also be taken into account, which is defined as an increase in the level of adherence of the patient on the dates close to the day of the clinical visit. This would cause the medical test to evaluate the concentration of metabolites to reflect a different level of medication to that which corresponds to the dose that the patient is usually administered in the interstage between clinical visits [1]. [1] Lam, W. Y., & Fresco, P. (2015). Medication Adherence Measures: An Overview. BioMed Research International. e217047. https://doi.org/10.1155/2015/217047 [2]Manuscript, A., Blood, W., & Count, C. (2009). NIH Public Access, 49(18), 1841–1850. https://doi.org/10.1016/j.jacc.2007.01.076.White. [3] Lee, C. S., Tan, J. H. M., Sankari, U., Koh, Y. L. E., & Tan, N. C. (2017). Assessing oral medication adherence among patients with type 2 diabetes mellitus treated with polytherapy in a developed Asian community: a cross-sectional study. BMJ Open, 7(9), e016317. https://doi.org/10.1136/bmjopen-2017-016317

12893009 | Biological |

Biological

Biological

12893009

http://www.semanticweb.org/parracarlos/ontologies/2019/3/untitled-ontology-31#Indicators