loading...| Preferred Name |
Cyclosporine |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClassfe7cc9e2_840a_40ec_be17_139114a835f5 |
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| Chinese |
环孢素 |
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| label |
Cyclosporine |
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| MESH_Definition |
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed). |
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| NCIt_Definition |
A natural cyclic polypeptide immunosuppressant isolated from the fungus Beauveria nivea. The exact mechanism of action of cyclosporine is not known but may involve binding to the cellular protein cytophilin, resulting in inhibition of the enzyme calcineurin. This agent appears to specifically and reversibly inhibit immunocompetent lymphocytes in the G0-or G1-phase of the cell cycle. T-lymphocytes are preferentially inhibited with T-helper cells as the primary target. Cyclosporine also inhibits lymphokine production and release. (NCI04) |
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| prefLabel |
Cyclosporine |
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| Synonyms |
Cyclosporine A Ciclosporinum ciclosporin Ciclosporin (substance) 27-400 Ciclosporina Cyclosporine Ciclosporin-containing product 59865-13-3 290193 cyclosporin CsA Product containing ciclosporin (medicinal product) Sangcya SandIMMUNE Ciclosporin A CYSP neoral OL 27-400 cyclosporin A Cyclosporine-containing product Cyclosporine Modified OL 27 400 Ciclosporine Sandimmun Gengraf CyA OL 27400 |
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