loading...| Preferred Name |
Proton pump inhibitor |
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| Synonyms |
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| ID |
http://www.semanticweb.org/administrator/ontologies/2022/0/untitled-ontology-34#OWLClass18300cab_e234_4299_8e3d_9274508502aa |
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| Chinese |
质子泵抑制剂 |
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| label |
Proton pump inhibitor |
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| MESH_Definition |
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. |
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| NCIt_Definition |
Any one of the substituted benzimidazole compounds with anti-ulcer activity. A proton pump inhibitor is orally administered in the neutrally charged, inactive form and, upon entering the acidic environment of the parietal cell, gets protonated and converted into its active form. The active form will covalently and irreversibly bind to the proton pump, the H+/K+-ATPase, located on the surface of parietal cells. This leads to an inhibition of the transport of hydrogen ions, in exchange for potassium ions, into the gastric lumen and results in an inhibition of gastric acid secretion. |
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| prefLabel |
Proton pump inhibitor |
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| Synonyms |
Proton Pump Inhibitor Proton Pump Inhibitors Product containing hydrogen/potassium adenosine triphosphatase enzyme system inhibitor (product) Substance with hydrogen/potassium adenosine triphosphatase enzyme system inhibitor mechanism of action (substance) H+/K+-exchanging ATPase inhibitor Substance with H+/K+-exchanging ATPase inhibitor mechanism of action Proton pump inhibitor-containing product Pump Inhibitor Proton H+/K+-exchanging ATPase inhibitor-containing product Inhibitors Proton Pump PPI Inhibitor Proton Pump |
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