Combined Phenotype Ontology

Last uploaded: November 18, 2021
Preferred Name

nucleus raphe magnus

Synonyms

magnus raphe nucleus

nucleus raphes magnus

raphe magnus nucleus

raphe magnus

red nucleus, magnocellular division

nucleus raphC) magnus

Definitions

The nucleus raphe magnus, located directly rostral to the raphe obscurus, is afferently stimulated from axons in the spinal cord and cerebellum. This makes the magnus a likely candidate for part of the motor system; however, it seems to participate in the endogenous analgesia system. The magnus receives descending afferents from the periaqueductal gray, the paraventricular hypothalamic nucleus, central nucleus of the amygdala, lateral hypothalamic area, parvocellular reticular nucleus and the prelimbic, infralimbic, medial and lateral precentral cortices . All of these brain areas influence the main function of the raphe magnus. The main function of the magnus is mostly pain mediation; in fact it sends projections to the dorsal horn of the spinal cord to directly inhibit pain. The periaquiductal gray, the epicenter of analgesia, sends efferent connections to the nucleus raphe magnus in when it is stimulated by opiates (endogenous or otherwise). Electrical stimulation of the PAG produces analgesia, as well as administration of morphine to the PAG or n.r. magnus. The antinociceptic effects of electrical stimulation of the PAG can be blocked by administering naloxone, an opiate antagonist, to the n.r. magnus. All of this seems to indicate that the magnus is part of the endogenous opiate system, and acts to inhibit pain in the spinal cord. [WP,unvetted].

ID

http://purl.obolibrary.org/obo/UBERON_0002156

database_cross_reference

UMLS:C0175515

EFO:0002518

BIRNLEX:1363

EMAPA:35720

Wikipedia:Nucleus_raphe_magnus

neuronames:739

MESH:D065846

BAMS:RM

BAMS:RMg

DHBA:12642

FMA:72584

HBA:9643

MA:0001024

MBA:206

definition

The nucleus raphe magnus, located directly rostral to the raphe obscurus, is afferently stimulated from axons in the spinal cord and cerebellum. This makes the magnus a likely candidate for part of the motor system; however, it seems to participate in the endogenous analgesia system. The magnus receives descending afferents from the periaqueductal gray, the paraventricular hypothalamic nucleus, central nucleus of the amygdala, lateral hypothalamic area, parvocellular reticular nucleus and the prelimbic, infralimbic, medial and lateral precentral cortices . All of these brain areas influence the main function of the raphe magnus. The main function of the magnus is mostly pain mediation; in fact it sends projections to the dorsal horn of the spinal cord to directly inhibit pain. The periaquiductal gray, the epicenter of analgesia, sends efferent connections to the nucleus raphe magnus in when it is stimulated by opiates (endogenous or otherwise). Electrical stimulation of the PAG produces analgesia, as well as administration of morphine to the PAG or n.r. magnus. The antinociceptic effects of electrical stimulation of the PAG can be blocked by administering naloxone, an opiate antagonist, to the n.r. magnus. All of this seems to indicate that the magnus is part of the endogenous opiate system, and acts to inhibit pain in the spinal cord. [WP,unvetted].

depiction

http://upload.wikimedia.org/wikipedia/commons/9/94/Gray694.png

has exact synonym

magnus raphe nucleus

nucleus raphes magnus

raphe magnus nucleus

has related synonym

raphe magnus

nucleus raphes magnus

red nucleus, magnocellular division

nucleus raphC) magnus

has_obo_namespace

uberon

id

UBERON:0002156

in_subset

http://purl.obolibrary.org/obo/uberon/core#efo_slim

http://purl.obolibrary.org/obo/uberon/core#pheno_slim

http://purl.obolibrary.org/obo/uberon/core#uberon_slim

label

nucleus raphe magnus

notation

UBERON:0002156

part_of

http://purl.obolibrary.org/obo/UBERON_0002692

prefixIRI

UBERON:0002156

prefLabel

nucleus raphe magnus

RO_0002171

http://purl.obolibrary.org/obo/UBERON_0002157

http://purl.obolibrary.org/obo/UBERON_0002684

treeView

http://purl.obolibrary.org/obo/UBERON_0002692

subClassOf

http://purl.obolibrary.org/obo/UBERON_0007635

Delete Subject Author Type Created
No notes to display