Combined Phenotype Ontology

Last uploaded: November 18, 2021
Preferred Name

neuromuscular junction

Synonyms

motor endplate

NMJ

Definitions

In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.

ID

http://purl.obolibrary.org/obo/GO_0031594

comment

In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.

In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT.

database_cross_reference

Wikipedia:Neuromuscular_junction

NIF_Subcellular:sao1124888485

definition

The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.

has related synonym

motor endplate

NMJ

has_obo_namespace

cellular_component

id

GO:0031594

label

neuromuscular junction

notation

GO:0031594

overlaps

http://purl.obolibrary.org/obo/CL_0000187

http://purl.obolibrary.org/obo/CL_0000100

prefixIRI

GO:0031594

prefLabel

neuromuscular junction

subClassOf

http://purl.obolibrary.org/obo/GO_0045202

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