Decreased functionality of the tissue.
http://purl.obolibrary.org/obo/UPHENO_0066921
http://purl.obolibrary.org/obo/UPHENO_0066925
http://purl.obolibrary.org/obo/UPHENO_0024906
http://purl.obolibrary.org/obo/UPHENO_0002252