Combined Phenotype Ontology

Last uploaded: November 18, 2021
Preferred Name

Renal tubular epithelial necrosis
Synonyms

Renal tubular necrosis

Acute tubular necrosis

Definitions

Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%). Renal tubular epithelial necrosis is a histomorphological definition that corresponds to the clinical term of acture tubular necrosis. Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis. The clinical course of acute tubular necrosis may be divided into initiation, maintenance, and recovery phases.

ID

http://purl.obolibrary.org/obo/HP_0008682

comment

Renal tubular epithelial necrosis is a histomorphological definition that corresponds to the clinical term of acture tubular necrosis. Acute death of renal tubular cells that usually results from prolonged renal ischemia, nephrotoxins, or sepsis. The clinical course of acute tubular necrosis may be divided into initiation, maintenance, and recovery phases.

database_cross_reference

SNOMEDCT_US:35455006

MSH:D007683

UMLS:C0022672

definition

Coagulative necrosis of tubular epithelial cells, defined as cells with increased cytoplasmic eosinophilia and nucleus that has a condensed chromatin pattern with fuzzy nuclear contour or has barely visible nuclear basophilic staining. The extent of cortical tubular necrosis is scoredsemiquantitatively as none, mild (less than 25% tubules with necrosis), moderate (25-50 percent), and severe (over 50%).

equivalentClass

http://purl.obolibrary.org/obo/MP_0004154

has exact synonym

Renal tubular necrosis

Acute tubular necrosis

id

HP:0008682

label

Renal tubular epithelial necrosis

notation

HP:0008682

prefLabel

Renal tubular epithelial necrosis

subClassOf

http://purl.obolibrary.org/obo/MP_0002703

http://purl.obolibrary.org/obo/HP_0000091

http://purl.obolibrary.org/obo/HP_0032618

http://purl.obolibrary.org/obo/MP_0003946

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