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Toxic Process Ontology
| Preferred Name | I-kappaB kinase/NF-kappaB signaling | |
| Synonyms |
I-kappaB kinase-NF-kappaB signal transduction pathway |
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| Definitions |
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. PMID:12773372 |
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| ID |
http://purl.obolibrary.org/obo/GO_0007249 |
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| definition |
The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. PMID:12773372
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| has part |
http://purl.obolibrary.org/obo/TXPO_0002779 http://purl.obolibrary.org/obo/TXPO_0002785 http://purl.obolibrary.org/obo/TXPO_0002781 |
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| has_exact_synonym |
I-kappaB kinase-NF-kappaB signal transduction pathway
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| label |
I-kappaB kinase/NF-kappaB signaling
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| prefixIRI |
GO:0007249
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| prefLabel |
I-kappaB kinase/NF-kappaB signaling
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| subClassOf |
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