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Thyroid Cancer Ontology
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July 2, 2020
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| Id | http://www.semanticweb.org/hx-jta/ontologies/thyroid_cancer_ontology#Carboplatin
http://www.semanticweb.org/hx-jta/ontologies/thyroid_cancer_ontology#Carboplatin
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|---|---|
| Preferred Name | Carboplatin |
| Definitions |
A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| prefLabel |
Carboplatin
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|---|---|
| NCI_code |
C1282
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| URL | |
| subClassOf | |
| type | |
| synonyms |
1,1-cyclobutanedicarboxylic acid platinum complexBlastocarb
Carboplatin
(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum
Nealorin
platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)
cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II)
Platinwa
Carbosol
Paraplatin
Paraplat
Carbosin
Paraplatine
Carbotec
Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum
CBDCA
Carboplatin Hexal
cis-diammine(cyclobutanedicarboxylato)platinum II
Carboplatinum
Paraplatin AQ
Displata
Carboplat
Ribocarbo
carboplatin
JM-8
Ercar
CARBOPLATIN
Carboplatino
Novoplatinum
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| Definition |
A second-generation platinum compound with a broad spectrum of antineoplastic properties. Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue. This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition. This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)
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| ChineseLabel |
卡铂
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