SNOMED CT, US Edition

Last uploaded: March 22, 2026
Id http://purl.bioontology.org/ontology/SNOMEDCT/719600006
http://purl.bioontology.org/ontology/SNOMEDCT/719600006
Preferred Name

1p21.3 microdeletion syndrome

Definitions
1p21.3 microdeletion syndrome is an extremely rare chromosomal anomaly characterised by severe speech and language delay, intellectual deficiency, autism spectrum disorder. 1p21.3 microdeletion syndrome is an extremely rare chromosomal anomaly characterized by severe speech and language delay, intellectual deficiency, autism spectrum disorder. An extremely rare chromosomal anomaly with characteristics of severe speech and language delay, intellectual deficiency, autism spectrum disorder. Less than 10 cases have been reported to date. The syndrome is caused by a hemizygous interstitial microdeletion on the short arm of chromosome 1, occurring mostly de novo, that implicates DPYD (dihydropyrimidine dehydrogenase) and MIR137 genes associated with miRNA pathways.
Synonyms
Monosomy 1p21.3
1p21.3 microdeletion syndrome (disorder)
Type http://www.w3.org/2002/07/owl#Class
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