Sepsis Ontology

Last uploaded: May 14, 2024
Preferred Name

Alpha Chemokine

Synonyms
ID

http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Alpha_Chemokine

definition

Members of the Alpha-Chemokines are referred to also as the 4q chemokine family because the genes encoding members of this family map to human chromosome 4q12-21. The first two cysteine residues of members of this family are separated by a single amino acids and these proteins, therefore, are called also CXC-Chemokines. Some members of the subgroup of the human CXC-Chemokines are defined by the conserved ELR sequence motif (glutamic acid-leucine-arginine) immediately preceding the first cysteine residue near the amino-terminal end. Chemokines with an ELR sequence motif have been found to chemoattract and activate primarily neutrophils. Chemokines without the ELR sequence motif appear to chemoattract and activate monocytes, dendritic cells, T-cells, NK-cells, B-lymphocytes, basophils, and eosinophils.

label

Alpha Chemokine

prefixIRI

Alpha_Chemokine

prefLabel

Alpha Chemokine

reference

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C20467

Synonyms

C-X-C Chemokine Chemokine, CXC 4q Chemokine CXC Chemokine Alpha Chemokine

subClassOf

http://www.semanticweb.org/zchero/ontologies/2023/11/SepsisOntology#Chemokine

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