Radiation Oncology Ontology

Last uploaded: June 19, 2018
Preferred Name

Irinotecan

Synonyms
Definitions

A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

ID

http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62040

definition

A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata. Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death. Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent.

isDefinedBy

http://purl.bioontology.org/ontology/NCIT

label

Irinotecan

prefixIRI

ncit:C62040

prefLabel

Irinotecan

seeAlso

EuroCAT Umbrella Protocol for NSCLC

subClassOf

http://purl.bioontology.org/ontology/STY/T121

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http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62040 NCIT SAME_URI
http://purl.obolibrary.org/obo/CHEBI_80630 OBA LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C62040 NCIT LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0123931 OCHV LOOM
http://purl.bioontology.org/ontology/NDFRT/N0000022032 NDFRT LOOM
http://www.drugbank.ca/drugs/DB00762 FTC LOOM
http://purl.obolibrary.org/obo/CHEBI_80630 EFO LOOM
http://purl.obolibrary.org/obo/CHEBI_80630 PDRO LOOM
http://purl.obolibrary.org/obo/CHEBI_80630 FIDEO LOOM
http://purl.obolibrary.org/obo/CHEBI_80630 BERO LOOM
http://purl.obolibrary.org/obo/CHEBI_80630 DRON LOOM
http://purl.obolibrary.org/obo/CHEBI_80630 OBA LOOM
http://purl.obolibrary.org/obo/CHEBI_80630 CHEBI LOOM
https://go.drugbank.com/drugs/DB00762 MDM LOOM
http://purl.bioontology.org/ontology/RXNORM/51499 RXNORM LOOM
http://purl.bioontology.org/ontology/MESH/D000077146 MESH LOOM
http://www.co-ode.org/ontologies/galen#Irinotecan GALEN LOOM
http://www.phoc.org.cn/pmo/class/PMO_00026193 PMAPP-PMO LOOM
http://purl.bioontology.org/ontology/ATC/L01CE02 ATC LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#C051890 RH-MESH LOOM
http://purl.bioontology.org/ontology/CSP/4009-0014 CRISP LOOM
http://purl.bioontology.org/ontology/VANDF/4024027 VANDF LOOM
http://purl.bioontology.org/ontology/NDDF/005262 NDDF LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#16325 OCHV LOOM
http://purl.obolibrary.org/obo/NCIT_C62040 BERO LOOM
http://purl.obolibrary.org/obo/dinto_DB00762 DINTO LOOM
http://purl.jp/bio/4/id/200906060658722270 IOBC LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/372538008 SNOMEDCT LOOM
http://stirdf.jst.go.jp/id/200907064751838008 IOBC LOOM