Preferred Name | Leukemia, chronic myeloid | |
Synonyms |
CML |
|
Definitions |
(ACML) - A myeloproliferative disorder that shares clinical and laboratory features with chronic myeloid leukemia but lacks the pathognomonic Philadelphia chromosome and the corresponding BCR|ABL1 fusion transcript. Features include myeloid predominance in the bone marrow, myeloid proliferation and low leukocyte alkaline phosphatase value, splenomegaly, hepatomegaly, elevated white blood cell count. Enlarged spleen may also be associated with a hypermetabolic state, fever, weight loss, and chronic fatigue. The enlarged liver may contribute to the patient's weight loss. - (CML) - A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. |
|
ID |
http://identifiers.org/omim/608232 |
|
altLabel |
CML |
|
definition |
(ACML) - A myeloproliferative disorder that shares clinical and laboratory features with chronic myeloid leukemia but lacks the pathognomonic Philadelphia chromosome and the corresponding BCR|ABL1 fusion transcript. Features include myeloid predominance in the bone marrow, myeloid proliferation and low leukocyte alkaline phosphatase value, splenomegaly, hepatomegaly, elevated white blood cell count. Enlarged spleen may also be associated with a hypermetabolic state, fever, weight loss, and chronic fatigue. The enlarged liver may contribute to the patient's weight loss. - (CML) - A clonal myeloproliferative disorder of a pluripotent stem cell with a specific cytogenetic abnormality, the Philadelphia chromosome (Ph), involving myeloid, erythroid, megakaryocytic, B-lymphoid, and sometimes T-lymphoid cells, but not marrow fibroblasts. |
|
id |
OMIM:608232 |
|
notation |
OMIM:608232 |
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prefLabel |
Leukemia, chronic myeloid |
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subClassOf |
Delete | Mapping To | Ontology | Source |
---|---|---|---|
http://identifiers.org/omim/608232 | GEXO | SAME_URI | |
http://identifiers.org/omim/608232 | RETO | SAME_URI | |
http://purl.bioontology.org/ontology/OMIM/608232 | OMIM | LOOM | |
http://identifiers.org/omim/608232 | GEXO | LOOM | |
http://identifiers.org/omim/608232 | RETO | LOOM |