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REGN_GO
| Preferred Name | SAGA complex | |
| Synonyms |
SPT3-TAF9-PCAF acetylase complex PCAF complex PCAF histone acetylase-associated complex STAGA coactivator complex STAGA complex SPT3-TAF9-GCN5 acetylase complex Spt-Ada-Gcn5-acetyltransferase complex |
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| Definitions |
A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695). |
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| ID |
http://purl.obolibrary.org/obo/GO_0000124 |
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| definition |
A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).
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| has part | ||
| has_alternative_id |
GO:0000125 GO:0030914
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| has_exact_synonym |
Spt-Ada-Gcn5-acetyltransferase complex
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| has_narrow_synonym |
SPT3-TAF9-PCAF acetylase complex PCAF complex PCAF histone acetylase-associated complex
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| has_obo_namespace |
cellular_component
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| has_related_synonym |
STAGA coactivator complex STAGA complex SPT3-TAF9-GCN5 acetylase complex
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| id |
GO:0000124
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| label |
SAGA complex
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| notation |
GO:0000124
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| prefLabel |
SAGA complex
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| subClassOf |
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