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Protein Ontology
Last uploaded:
November 12, 2025
| Id | http://purl.obolibrary.org/obo/PR_000030035
http://purl.obolibrary.org/obo/PR_000030035
|
|---|---|
| Preferred Name | G-protein coupled receptor |
| Definitions |
Category=family. Classification based on GRAFS system. [PMID:12761335]
A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit.
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| Synonyms |
fam:GPCR
seven-transmembrane receptor
7TM receptor
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| definition | A protein that has G protein-coupled receptor (GPCR) activity. Each GPCR consists of a single polypeptide with an extracellular N-terminus, an intracellular C-terminus and seven hydrophobic transmembrane domains (TM1-TM7) linked by three extracellular loops (ECL1-ECL3) and three intracellular loops (ICL1-ICL3). GPCRs function as part of a heterotrimeric complex to transmit an extracellular signal across the membrane by activating an associated G-protein via the exchange of GDP for GTP on the alpha subunit. |
|---|---|
| prefLabel | G-protein coupled receptor
|
| label | G-protein coupled receptor
|
| comment | Category=family. Classification based on GRAFS system. [PMID:12761335]
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| has_exact_synonym | fam:GPCR
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| has_obo_namespace | protein
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| type | |
| id | PR:000030035
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| capable_of | |
| notation | PR:000030035
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| database_cross_reference | IUPHARfam:694
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| treeView | |
| has_broad_synonym |
seven-transmembrane receptor
7TM receptor
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| subClassOf |
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