loading...| Preferred Name |
tumor necrosis factor |
|
| Synonyms |
TNFA TNFSF2 TNF TNF-a TNF-alpha tumor necrosis factor ligand superfamily member 2 TNFa tumor necrosis factor alpha cachectin |
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| Definitions |
A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. Category=gene. |
|
| ID |
http://purl.obolibrary.org/obo/PR_000000134 |
|
| comment |
Category=gene. |
|
| database_cross_reference |
PIRSF:PIRSF500467 |
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| definition |
A tumor necrosis factor, TNF-like that is a translation product of the human TNF gene or a 1:1 ortholog thereof. Tumour necrosis factor alpha (TNF) is a pleiotropic cytokine that mediates apoptosis, cell proliferation, immunomodulation, inflammation, viral replication, allergy, arthritis, septic shock, insulin resistance, autoimmune diseases, and other pathological conditions. TNF transduces these cellular responses through two distinct receptors: type I, which are expressed on all cell types, and type II, which are expressed only on cells of the immune system and endothelial cells. |
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| has_exact_synonym |
TNF TNF-a TNF-alpha tumor necrosis factor ligand superfamily member 2 TNFa tumor necrosis factor alpha cachectin |
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| has_obo_namespace |
protein |
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| has_related_synonym |
TNFA TNFSF2 |
|
| id |
PR:000000134 |
|
| label |
tumor necrosis factor |
|
| notation |
PR:000000134 |
|
| prefLabel |
tumor necrosis factor |
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| treeView | ||
| subClassOf |
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