PRO Term Request Guidelines

> Superclass
If you are familiar with PRO and know the name or PRO ID of the parent (superclass) of the term you are requesting, enter the name or ID in the “Jump to:” text box. If you don’t know the parent, enter “protein”; in this case, your term will temporarily be created as a child of the class “protein” and will be positioned correctly in the PRO hierarchy by a PRO curator. A menu of classes that match your request will appear; select the appropriate class. Once the selected class is loaded, click on the Term Request tab and then on the Request New Term link. The Superclass field on the request form should already be filled in with the parent class you selected.

>Term Label
If you are familiar with PRO, follow the conventions for PRO term naming (e.g., “alpha-crystallin B chain acetylated 1 (mouse)”); otherwise, just enter “label” and PRO curators will determine the correct name.

>Term Description
Provide the name of the protein, the organism, and as much information as possible about the sequence. If appropriate, provide a UniProtKB identifier. If you are requesting a term for a specific isoform of a protein, use the UniProtKB isoform identifier or TrEMBL identifier, as appropriate. Describe any modifications in relation to the sequence specified by the identifier.
Example: “mouse Smad2 short isoform; UniProtKB: Q62432-2”
Example: “human epidermal growth factor receptor, signal sequence (amino acids 1-24) removed; UniProtKB: P00533, residues 25-1210”
Example: “human epidermal growth factor receptor, phosphorylated on tyrosine 1069 and N-glycosylated on asparagine 352; UniProtKB: P00533, phosphorylation: Y1069, N-linked glycosylation N352”

>References
Provide evidence for the existence of the requested term such as PMIDs of papers or links to other resources that describe the protein form.

>Justification (optional)
Provide any additional information about the requested term here. If you would like to include any annotation for your term in the PRO Annotation File (PAF), describe it here. Be as specific as possible about the annotation using references to other ontologies (e.g., Gene Ontology for molecular function annotations) whenever possible.