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PMO Precision Medicine Ontology
Last uploaded:
December 16, 2020
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| Id | http://www.phoc.org.cn/pmo/class/PMO_00069430
http://www.phoc.org.cn/pmo/class/PMO_00069430
|
|---|---|
| Preferred Name | Bone Remodeling |
| Definitions |
"The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators]
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| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
Bone Remodeling
|
|---|---|
| prefLabel |
Bone Remodeling
|
| Gene Annotation |
EFNA2(UniProtKB:O43921)
LRP5L(UniProtKB:A4QPB2)
EPHA2(UniProtKB:P29317)
MITF(UniProtKB:O75030)
LGR4(UniProtKB:Q9BXB1)
LRP5(UniProtKB:O75197)
P3H4(UniProtKB:Q92791)
WNT16(UniProtKB:Q9UBV4)
EFNA4(UniProtKB:P52798)
SPP2(UniProtKB:Q13103)
NOTCH2(UniProtKB:Q04721)
HTR1B(UniProtKB:P28222)
RASSF2(UniProtKB:P50749)
GJA1(UniProtKB:P17302)
TPH1(UniProtKB:P17752)
LRP6(UniProtKB:O75581)
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|
| Synonym |
"bone remodelling" EXACT []
|
| Definition |
"The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis." [GOC:curators]
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| PMOID |
PMO:00069430
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| MCID |
MC04792087
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| prefixIRI |
pmo:PMO_00069430
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| Database_Cross_Reference |
GO:0046849
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| Tree Number |
T10.1.25.38.2
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| subClassOf | |
| type |
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