PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
Preferred Name

RNA Interference
Synonyms
Definitions

"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]

ID

http://www.phoc.org.cn/pmo/class/PMO_00065942

Database_Cross_Reference

GO:0016246

Definition

"The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]

Gene Annotation

NRDE2(UniProtKB:Q9H7Z3)

CELF1(UniProtKB:Q92879)

label

RNA Interference

MCID

MC04769019

PMOID

PMO:00065942

prefixIRI

pmo:PMO_00065942

prefLabel

RNA Interference

Synonym

"posttranscriptional gene silencing by siRNA" EXACT [GOC:mah]

"RNAi" EXACT []

Tree Number

T10.1.29.35.1.4.2

T10.1.26.1.16.17.7.7.12.2.4.2

T10.1.26.1.16.17.1.6.12.2.4.2

T10.1.26.1.16.17.7.8.3.4.2

T10.1.26.1.16.9.1.6.12.1.4.2

T10.1.26.1.1.18.1.6.12.2.4.2

T10.1.26.1.16.17.7.7.12.1.4.2

T10.1.29.35.2.4.2

T10.1.26.1.16.17.1.6.12.1.4.2

T10.1.26.1.16.17.7.9.3.4.2

T10.1.26.1.1.18.1.6.12.1.4.2

T10.1.26.1.16.9.1.6.12.2.4.2

subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00065941

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