PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
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Id http://www.phoc.org.cn/pmo/class/PMO_00064512
http://www.phoc.org.cn/pmo/class/PMO_00064512
Preferred Name

Necrotic Cell Death
Definitions
"A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]
Type http://www.w3.org/2002/07/owl#Class

All Properties

label
Necrotic Cell Death
prefLabel
Necrotic Cell Death
Gene Annotation
GSDME(UniProtKB:O60443)
Synonym
"necrosis" BROAD [GOC:mah]
"cellular necrosis" EXACT [GOC:add]
Definition
"A type of cell death that is morphologically characterized by an increasingly translucent cytoplasm, swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. Necrotic cells do not fragment into discrete corpses as their apoptotic counterparts do. Moreover, their nuclei remain intact and can aggregate and accumulate in necrotic tissues." [GOC:mtg_apoptosis, PMID:18846107, PMID:20823910]
PMOID
PMO:00064512
MCID
MC04798394
prefixIRI
pmo:PMO_00064512
Database_Cross_Reference
GO:0070265
Tree Number
T10.1.29.54.4
subClassOf
type
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