PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
Preferred Name

Cell Death
Synonyms
Definitions

"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]

ID

http://www.phoc.org.cn/pmo/class/PMO_00064405

Database_Cross_Reference

GO:0008219

Definition

"Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395]

Gene Annotation

FAF1(UniProtKB:Q9UNN5)

OPTN(UniProtKB:Q96CV9)

EIF4G2(UniProtKB:P78344)

FOSL2(UniProtKB:P15408)

SUSD6(UniProtKB:Q92537)

PNPLA8(UniProtKB:Q9NP80)

IL17A(UniProtKB:Q16552)

ALS2(UniProtKB:Q96Q42)

RRAGA(UniProtKB:Q7L523)

BNIP3(UniProtKB:Q12983)

TGFB2(UniProtKB:P61812)

BRINP1(UniProtKB:O60477)

PRKD2(UniProtKB:Q9BZL6)

EMP2(UniProtKB:P54851)

EMP3(UniProtKB:P54852)

NUP62(UniProtKB:P37198)

GSDME(UniProtKB:O60443)

FBH1(UniProtKB:Q8NFZ0)

HTR2A(UniProtKB:P28223)

MAP3K20(UniProtKB:Q9NYL2)

SNCAIP(UniProtKB:Q9Y6H5)

KLK8(UniProtKB:O60259)

VAPA(UniProtKB:Q9P0L0)

NDOR1(UniProtKB:Q9UHB4)

HMOX1(UniProtKB:P09601)

EMP1(UniProtKB:P54849)

MAP3K11(UniProtKB:Q16584)

BCL10(UniProtKB:O95999)

CIDEA(UniProtKB:O60543)

PMP22(UniProtKB:Q01453)

CACNA1A(UniProtKB:O00555)

PTGER3(UniProtKB:P43115)

GZMM(UniProtKB:P51124)

PARP4(UniProtKB:Q9UKK3)

SGCD(UniProtKB:Q92629)

label

Cell Death

MCID

MC04776753

PMOID

PMO:00064405

prefixIRI

pmo:PMO_00064405

prefLabel

Cell Death

Synonym

"accidental cell death" RELATED []

"necrosis" RELATED []

Tree Number

T10.1.29.54

subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00062856

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Delete Mapping To Ontology Source
http://purl.obolibrary.org/obo/GO_0008219 CL LOOM
http://purl.org/obo/owl/GO#GO_0008219 NPO LOOM
http://purl.org/obo/owl/GO#GO_0008219 BIOMODELS LOOM
http://www.bootstrep.eu/ontology/GRO#CellDeath GRO LOOM
http://doe-generated-ontology.com/OntoAD#C0007587 ONTOAD LOOM
http://localhost/plosthes.2017-1#5783 PLOSTHES LOOM
http://regenbase.org/ontology#RB_0000152 RB LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#G04.299.139 RH-MESH LOOM
http://purl.obolibrary.org/obo/MPATH_2 MPATH LOOM
http://purl.obolibrary.org/obo/MESH_D016923 BERO LOOM
http://www.ustb.edu.cn/thesauri/tocr/v1/data#C571345044435365904 ACVD_ONTOLOGY LOOM
http://purl.obolibrary.org/obo/IEV_0000097 PTS LOOM
http://purl.obolibrary.org/obo/APO_0000312 APO LOOM
http://purl.obolibrary.org/obo/APO_0000312 UPHENO LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#C0007587 OCHV LOOM
http://phenomebrowser.net/ontologies/mesh/mesh.owl#D016923 RH-MESH LOOM
http://www.semanticweb.org/ADMO#cellDeath ADMO LOOM
http://cbo.biocomplexity.indiana.edu/svn/cbo/trunk/CBO_1_1_2.owl#CellDeath CBO LOOM
http://purl.bioontology.org/ontology/MEDDRA/10057248 MEDDRA LOOM
http://purl.bioontology.org/ontology/CSP/0599-7346 CRISP LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#2584 OCHV LOOM
http://scai.fraunhofer.de/CSEO#CSEO_00000818 CSEO LOOM
http://id.nlm.nih.gov/mesh/D016923 MDM LOOM
http://purl.jp/bio/4/id/200906029557537192 IOBC LOOM
http://purl.obolibrary.org/obo/OMIT_0017353 OMIT LOOM
http://purl.obolibrary.org/obo/GO_0008219 NIGO LOOM
http://purl.obolibrary.org/obo/GO_0008219 OAE LOOM
http://purl.obolibrary.org/obo/GO_0008219 GO-EXT LOOM
http://purl.obolibrary.org/obo/GO_0008219 UBERON LOOM
http://purl.obolibrary.org/obo/GO_0008219 CLO LOOM
http://purl.obolibrary.org/obo/GO_0008219 PLANP LOOM
http://purl.obolibrary.org/obo/GO_0008219 GCBO LOOM
http://purl.obolibrary.org/obo/GO_0008219 CCONT LOOM
http://purl.obolibrary.org/obo/GO_0008219 FOVT LOOM
http://purl.obolibrary.org/obo/GO_0008219 HOIP LOOM
http://purl.obolibrary.org/obo/GO_0008219 RBO LOOM
http://purl.obolibrary.org/obo/GO_0008219 OBI_BCGO LOOM
http://purl.obolibrary.org/obo/GO_0008219 EFO LOOM
http://purl.obolibrary.org/obo/GO_0008219 XPO LOOM
http://purl.obolibrary.org/obo/GO_0008219 PHAGE LOOM
http://purl.obolibrary.org/obo/GO_0008219 CMPO LOOM
http://purl.obolibrary.org/obo/GO_0008219 PCL LOOM
http://purl.obolibrary.org/obo/GO_0008219 PATO LOOM
http://purl.obolibrary.org/obo/GO_0008219 BAO LOOM
http://purl.obolibrary.org/obo/GO_0008219 NIFDYS LOOM
http://purl.obolibrary.org/obo/GO_0008219 GO-PLUS LOOM
http://purl.obolibrary.org/obo/GO_0008219 DPO LOOM
http://purl.obolibrary.org/obo/GO_0008219 BERO LOOM
http://purl.obolibrary.org/obo/GO_0008219 EFO LOOM
http://purl.obolibrary.org/obo/GO_0008219 HHEAR LOOM
http://purl.obolibrary.org/obo/GO_0008219 TXPO LOOM
http://purl.obolibrary.org/obo/GO_0008219 INO LOOM
http://purl.obolibrary.org/obo/GO_0008219 UPHENO LOOM
http://purl.obolibrary.org/obo/GO_0008219 OCVDAE LOOM
http://purl.obolibrary.org/obo/GO_0008219 FTC LOOM
http://purl.obolibrary.org/obo/GO_0008219 NIFSTD LOOM
http://purl.obolibrary.org/obo/GO_0008219 ECAO LOOM
http://purl.obolibrary.org/obo/GO_0008219 KTAO LOOM
http://purl.obolibrary.org/obo/GO_0008219 PHIPO LOOM
http://purl.obolibrary.org/obo/GO_0008219 FYPO LOOM
http://purl.obolibrary.org/obo/GO_0008219 REGN_GO LOOM
http://purl.obolibrary.org/obo/GO_0008219 IDOMAL LOOM
http://purl.obolibrary.org/obo/GO_0008219 HINO LOOM
http://purl.obolibrary.org/obo/GO_0008219 MAXO LOOM
http://purl.obolibrary.org/obo/GO_0008219 GO LOOM
http://purl.obolibrary.org/obo/GO_0008219 IDODEN LOOM
http://purl.obolibrary.org/obo/GO_0008219 ZP LOOM
http://purl.obolibrary.org/obo/GO_0008219 AISM LOOM
http://purl.obolibrary.org/obo/GO_0008219 NMDCO LOOM
http://purl.obolibrary.org/obo/GO_0008219 OBA LOOM
http://www.semanticweb.org/ontologies/2008/8/SPO_lightweight_merged.owl#CellDeath SPO LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_6e11a25e_c888_474f_98db_38865e6df5ce STO-DRAFT LOOM
http://www.semanticweb.org/ontologies/STO.owl#OWLClass_6e11a25e_c888_474f_98db_38865e6df5ce CVAO LOOM
http://purl.bioontology.org/ontology/MESH/D016923 MESH LOOM