PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
Preferred Name

Smooth Endoplasmic Reticulum
Synonyms
Definitions

"The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732]

ID

http://www.phoc.org.cn/pmo/class/PMO_00053950

Database_Cross_Reference

GO:0005790

Definition

"The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732]

Gene Annotation

GBA2(UniProtKB:Q9HCG7)

SYVN1(UniProtKB:Q86TM6)

MYO1D(UniProtKB:O94832)

CANX(UniProtKB:P27824)

RYR1(UniProtKB:P21817)

RYR2(UniProtKB:Q92736)

GABARAP(UniProtKB:O95166)

KCNJ2(UniProtKB:P63252)

PLCB4(UniProtKB:Q15147)

PPIB(UniProtKB:P23284)

RPL10(UniProtKB:P27635)

MYO5A(UniProtKB:Q9Y4I1)

CASQ1(UniProtKB:P31415)

PSEN1(UniProtKB:P49768)

PRDX4(UniProtKB:Q13162)

RYR3(UniProtKB:Q15413)

DNAJC3(UniProtKB:Q13217)

TH(UniProtKB:P07101)

HYOU1(UniProtKB:Q9Y4L1)

APP(UniProtKB:P05067)

SLMAP(UniProtKB:Q14BN4)

ERP29(UniProtKB:P30040)

CALR(UniProtKB:P27797)

JPH4(UniProtKB:Q96JJ6)

APOB(UniProtKB:P04114)

SRI(UniProtKB:P30626)

HSPA5(UniProtKB:P11021)

label

Smooth Endoplasmic Reticulum

MCID

MC04808043

PMOID

PMO:00053950

prefixIRI

pmo:PMO_00053950

prefLabel

Smooth Endoplasmic Reticulum

Synonym

"SER" EXACT []

"smooth ER" EXACT []

Tree Number

T10.3.7.100.15.4.28.3

T10.3.4.1.4.28.3

T10.3.7.100.7.185.3

T10.3.4.4.4.28.3

subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00053949

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Delete Mapping To Ontology Source
http://uri.neuinfo.org/nif/nifstd/sao710427438 NIFSTD LOOM
http://sbmi.uth.tmc.edu/ontology/ochv#22573 OCHV LOOM
http://purl.obolibrary.org/obo/CLAO_0001208 CLAO LOOM
http://purl.org/sig/ont/fma/fma66897 FMA LOOM
http://ccdb.ucsd.edu/SAO/1.2#sao710427438 SAO LOOM
http://purl.obolibrary.org/obo/NCIT_C30121 BERO LOOM
http://purl.org/obo/owlapi/fma#FMA_66897 BIOMODELS LOOM
http://ontology.neuinfo.org/NIF/BiomaterialEntities/NIF-Subcellular.owl#sao710427438 NIFSUBCELL LOOM
http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C30121 NCIT LOOM
http://purl.bioontology.org/ontology/SNOMEDCT/770099009 SNOMEDCT LOOM
http://purl.obolibrary.org/obo/GO_0005790 NIGO LOOM
http://purl.obolibrary.org/obo/GO_0005790 GO-EXT LOOM
http://purl.obolibrary.org/obo/GO_0005790 PLANP LOOM
http://purl.obolibrary.org/obo/GO_0005790 HOIP LOOM
http://purl.obolibrary.org/obo/GO_0005790 CCO LOOM
http://purl.obolibrary.org/obo/GO_0005790 REXO LOOM
http://purl.obolibrary.org/obo/GO_0005790 GEXO LOOM
http://purl.obolibrary.org/obo/GO_0005790 PHAGE LOOM
http://purl.obolibrary.org/obo/GO_0005790 BERO LOOM
http://purl.obolibrary.org/obo/GO_0005790 EFO LOOM
http://purl.obolibrary.org/obo/GO_0005790 TXPO LOOM
http://purl.obolibrary.org/obo/GO_0005790 GO LOOM
http://purl.obolibrary.org/obo/GO_0005790 UPHENO LOOM
http://purl.obolibrary.org/obo/GO_0005790 NIFSTD LOOM
http://purl.obolibrary.org/obo/GO_0005790 REGN_GO LOOM
http://purl.obolibrary.org/obo/GO_0005790 GO-PLUS LOOM
http://purl.obolibrary.org/obo/GO_0005790 RETO LOOM
http://purl.obolibrary.org/obo/GO_0005790 ZP LOOM
http://purl.obolibrary.org/obo/PLANA_0007515 PLANA LOOM
http://purl.obolibrary.org/obo/PLANA_0007515 PLANP LOOM
http://www.projecthalo.com/aura#Smooth-Endoplasmic-Reticulum AURA LOOM
http://purl.org/obo/owl/GO#GO_0005790 BIOMODELS LOOM