PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
Preferred Name

Hemidesmosome

Synonyms
Definitions

"A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195]

ID

http://www.phoc.org.cn/pmo/class/PMO_00051566

Database_Cross_Reference

GO:0030056

Definition

"A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195]

Gene Annotation

ITGA6(UniProtKB:P23229)

COL17A1(UniProtKB:Q9UMD9)

ITGB4(UniProtKB:P16144)

JUP(UniProtKB:P14923)

EPPK1(UniProtKB:P58107)

ERBIN(UniProtKB:Q96RT1)

DST(UniProtKB:Q03001)

PLEC(UniProtKB:Q15149)

label

Hemidesmosome

MCID

MC04787292

PMOID

PMO:00051566

prefixIRI

pmo:PMO_00051566

prefLabel

Hemidesmosome

Synonym

"hemi-adherens junction" RELATED [http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction]

"trans-epithelial attachment" NARROW [GOC:kmv, PMID:20205195]

"epidermal attachment structure" NARROW [GOC:kmv]

"fibrous organelle" NARROW [GOC:kmv, PMID:20205195]

Tree Number

T10.3.1.1.2

subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00051560

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