loading...| Preferred Name |
Homologous Recombination |
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| Synonyms |
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| Definitions |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. |
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| ID |
http://www.phoc.org.cn/pmo/class/PMO_00014484 |
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| Database_Cross_Reference |
MTH:NOCODE CSP:1263-1512 MSH:D059765 CSP:4005-0020 NCI:C18144 |
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| Definition |
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR. |
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| label |
Homologous Recombination |
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| MCID |
MC00184090 |
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| PMOID |
PMO:00014484 |
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| prefixIRI |
pmo:PMO_00014484 |
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| prefLabel |
Homologous Recombination |
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| Synonym |
Recombinations, Homologous homologous recombination Recombination, Homologous Homologous Recombinations |
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| Tree Number |
T4.6.1 |
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| subClassOf |