PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
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Preferred Name

Homologous Recombination
Synonyms
Definitions

Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
ID

http://www.phoc.org.cn/pmo/class/PMO_00014484
Database_Cross_Reference

MTH:NOCODE

CSP:1263-1512

MSH:D059765

CSP:4005-0020

NCI:C18144
Definition

Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
label

Homologous Recombination
MCID

MC00184090
PMOID

PMO:00014484
prefixIRI

pmo:PMO_00014484
prefLabel

Homologous Recombination
Synonym

Recombinations, Homologous

homologous recombination

Recombination, Homologous

Homologous Recombinations
Tree Number

T4.6.1
subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00014480
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