PMO Precision Medicine Ontology

Last uploaded: December 16, 2020
Preferred Name

Upper Motor Neuron Dysfunction
Synonyms
Definitions

A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.

ID

http://www.phoc.org.cn/pmo/class/PMO_00010757

Database_Cross_Reference

OMIM:MTHU006792

OMIM:MTHU021486

HPO:HP:0002493

Definition

A functional anomaly of the upper motor neuron. The upper motor neurons are neurons of the primary motor cortex which project to the brainstem and spinal chord via the corticonuclear, corticobulbar and corticospinal (pyramidal) tracts. They are involved in control of voluntary movements. Dysfunction leads to weakness, impairment of fine motor movements, spasticity, hyperreflexia and abnormal pyramidal signs.

label

Upper Motor Neuron Dysfunction

MCID

MC00605379

PMOID

PMO:00010757

prefixIRI

pmo:PMO_00010757

prefLabel

Upper Motor Neuron Dysfunction

Synonym

Corticospinal tract dysfunction

Upper motor neuron dysfunction

Tree Number

T3.17.1.5.3

subClassOf

http://www.phoc.org.cn/pmo/class/PMO_00010701

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