Neurofibrillary tangles

60.110.120.470^Neurofibrillary tangles|60.360.140.470^Neurofibrillary tangles

Neurofibrillary tangles

Neurofibrillary Tangles (NFTs) are aggregates of hyperphosphorylated tau protein that are most commonly known as a primary marker of Alzheimer's disease. Their presence is also found in numerous other diseases known as tauopathies. Little is known about their exact relationship to the different pathologies. https://en.wikipedia.org/wiki/Neurofibrillary_tangle Alzheimer’s is generally associated with two types of lesions throughout the cerebral cortex: amyloid plaques, which are found between the neurons, and neurofibrillary tangles, which are found inside them. Neurons have a system of specialized filaments called microtubules that transport nutrients, organelles, and other essential materials from the cell body to the tip of the axon. These microtubules are somewhat like a pair of rails on a railroad, and the protein that acts as the ties that hold these rails together and keep them parallel is called the tau protein. In people with Alzheimer’s, the tau protein molecules disaggregate into filaments that form [neurofibrillary] tangles. http://thebrain.mcgill.ca/flash/d/d_08/d_08_cl/d_08_cl_alz/d_08_cl_alz.html RD

Accepted