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PLOS Thesaurus
Last uploaded:
September 21, 2017
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| Id | http://localhost/plosthes.2017-1#11368
http://localhost/plosthes.2017-1#11368
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| Preferred Name | Toxin-antitoxin modules |
| Type | http://www.w3.org/2004/02/skos/core#Concept |
All Properties
| prefLabel | Toxin-antitoxin modules
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| type | |
| Previous_Classification | 10.200.290.10.30^Toxin-antitoxin modules|10.230.40.40.30^Toxin-antitoxin modules|10.230.40.50.90^Toxin-antitoxin modules|10.230.120.20.90^Toxin-antitoxin modules|10.430.130.40.10.60^Toxin-antitoxin modules|60.360.170.130.40.10.60^Toxin-antitoxin modules
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| alpha | Toxin-antitoxin modules
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| scopeNote | Bacterial TA systems are of two different types depending on the nature of the antitoxin; the toxin always being a protein. The antitoxin of type I systems is a small RNA (antisense or adjacent and divergent to the toxin gene) showing complementarity to the toxin mRNA (for recent reviews on type I systems). Type I antitoxins regulate toxin expression by inhibiting the toxin's translation. The toxins of type I systems are small, hydrophobic proteins that cause damage in bacterial cell membranes. In type II systems, the antitoxin is a small, unstable protein that sequesters the toxin through proteic complex formation (for a recent review on type II systems). Much more information is available for type II systems, especially in terms of their biological roles. http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1000437 RD
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| broader | |
| status | Accepted
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