Restriction modification systems

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Restriction modification systems

A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme. http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0009307 RD Systems consisting of two enzymes, a modification methylase and a restriction endonuclease. They are closely related in their specificity and protect the DNA of a given bacterial species. The methylase adds methyl groups to adenine or cytosine residues in the same target sequence that constitutes the restriction enzyme binding site. The methylation renders the target site resistant to restriction, thereby protecting DNA against cleavage. http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi?mode=&index=14621&field=all&HM=&II=&PA=&form=&input= RD

Accepted