PLOS Thesaurus

Last uploaded: September 21, 2017

Id	http://localhost/plosthes.2017-1#11205 http://localhost/plosthes.2017-1#11205
Preferred Name	Inflammasomes
Type	http://www.w3.org/2004/02/skos/core#Concept

prefLabel	Inflammasomes
homepage	http://journals.plos.org/plosone/browse/inflammasomes
related	http://localhost/plosthes.2017-1#5405
type	http://www.w3.org/2004/02/skos/core#Concept http://www.w3.org/2002/07/owl#NamedIndividual
Previous_Classification	10.60.280.350.60^Inflammasomes\|10.210.130.60^Inflammasomes\|60.180.130.60^Inflammasomes
alpha	Inflammasomes
scopeNote	The inflammasome is a multiprotein oligomer consisting of caspase 1, PYCARD, NALP and sometimes caspase 5 (also known as caspase 11 or ICH-3). It is expressed in myeloid cells and is a component of the innate immune system. The exact composition of an inflammasome depends on the activator which initiates inflammasome assembly, e.g. dsRNA will trigger one inflammasome composition whereas asbestos will assemble a different variant. The inflammasome promotes the maturation of the inflammatory cytokines Interleukin 1β (IL-1β) and Interleukin 18 (IL-18). http://en.wikipedia.org/wiki/Inflammasome 2014/10/14 (RD)
broader	http://localhost/plosthes.2017-1#7827
status	Accepted

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