PLOS Thesaurus

Last uploaded: September 21, 2017

Id	http://localhost/plosthes.2017-1#11198 http://localhost/plosthes.2017-1#11198
Preferred Name	DNA helicases
Type	http://www.w3.org/2004/02/skos/core#Concept

prefLabel	DNA helicases
homepage	http://journals.plos.org/plosone/browse/dna_helicases
type	http://www.w3.org/2004/02/skos/core#Concept http://www.w3.org/2002/07/owl#NamedIndividual
Previous_Classification	10.60.150.60.70.10^DNA helicases\|10.60.280.230.70.10^DNA helicases
alpha	DNA helicases
scopeNote	DNA helicases are essential during DNA replication because they separate double-stranded DNA into single strands allowing each strand to be copied. During DNA replication, DNA helicases unwind DNA at positions called origins where synthesis will be initiated. DNA helicase continues to unwind the DNA forming a structure called the replication fork, which is named for the forked appearance of the two strands of DNA as they are unzipped apart. The process of breaking the hydrogen bonds between the nucleotide base pairs in double-stranded DNA requires energy. To break the bonds, helicases use the energy stored in a molecule called ATP, which serves as the energy currency of cells. DNA helicases also function in other cellular processes where double-stranded DNA must be separated, including DNA repair and transcription. http://www.nature.com/scitable/definition/helicase-307 2014/10/14 (RD)
broader	http://localhost/plosthes.2017-1#11197
status	Accepted

Delete	Subject	Author	Type	Created
No notes to display