PLOS Thesaurus

Last uploaded: September 21, 2017

Id	http://localhost/plosthes.2017-1#11081 http://localhost/plosthes.2017-1#11081
Preferred Name	Chicken models
Type	http://www.w3.org/2004/02/skos/core#Concept

prefLabel	Chicken models
homepage	http://journals.plos.org/plosone/browse/chicken_models
type	http://www.w3.org/2004/02/skos/core#Concept http://www.w3.org/2002/07/owl#NamedIndividual
Previous_Classification	90.170.10.30^Chicken models
alpha	Chicken models
scopeNote	Chickens have been invaluable for elucidating the molecular basis of limb development and cell migration in the nervous system. They have helped to uncover the molecular basis of many limb and neural defects in humans. http://genome.wellcome.ac.uk/doc_WTD020805.html Selection of appropriate animal models is essential to the advancement of basic and clinical research. This chapter provides an overview of the reproductive biology of the chicken (Gallus domesticus), also known as the domestic hen, and then introduces the chicken as a model for investigations of mechanisms controlling ovarian follicular growth and maturation, ovulation, and changes in ovarian function with aging. The chicken is currently the only animal model available to probe the etiology and progression of human ovarian cancer as well as to test chemotherapy agents. Finally the chicken is an ideal model for toxicology studies because of its sensitivity and rapid response to environmental toxicants and expression of external indicators, e.g., number of eggs laid, thickness of shell, as a mark of toxic exposure. http://link.springer.com/chapter/10.1007%2F978-1-59745-285-4_18 2014/09/16 RD
broader	http://localhost/plosthes.2017-1#8020
status	Accepted

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