http://localhost/plosthes.2017-1#10525

RNA interference

http://localhost/plosthes.2017-1#10599

http://localhost/plosthes.2017-1#6915

http://localhost/plosthes.2017-1#8715

http://localhost/plosthes.2017-1#7451

http://journals.plos.org/plosone/browse/rna_interference

http://localhost/plosthes.2017-1#978

http://localhost/plosthes.2017-1#8851

http://localhost/plosthes.2017-1#9680

http://localhost/plosthes.2017-1#8778

RNA interference

10.60.210.40.80^RNA interference|10.200.70.40^RNA interference|10.200.120.90^RNA interference|10.200.210.20^RNA interference

The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes. PMID:11201747 PMID:11713190 PMID:18771919 http://www.ebi.ac.uk/QuickGO/GTerm?id=GO:0016246 A gene silencing phenomenon whereby specific dsRNAs ( RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA ( RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process. http://www.nlm.nih.gov/cgi/mesh/2015/MB_cgi RD

Accepted

http://localhost/plosthes.2017-1#T0