http://www.semanticweb.org/ontologies/2010/3/Ontology1271664172453.owl#Intrinsic_activity

Intrinsic activity=(maximum responce to test agonist)/(maximum responce to full agonist acting through the same receptor)

Intrinsic activity is the maximal stimulatory response induced by a compound in relation to that of a given reference compound. It is a proportionality factor between tissue response and receptor occupancy.The numerical value of intrinsic activity (alpha) could range from unity (for full agonists, i.e., agonist inducing the tissue maximal response) to zero (for antagonists), the fractional values within this range denoting partial agonists. Intrinsic activity, which is a drug and tissue parameter, cannot be used as a characteristic drug parameter for classification of drugs or drug receptors. For this purpose, a proportionality factor derived by null methods, namely, relative efficacy, should be used. Intrinsic activity is the capacity to generate the responce.

Ontology1271664172453:Intrinsic_activity

Intrinsic_activity

http://www.chem.qmul.ac.uk/iupac/medchem/ix.html#i2 http://www.mc.uky.edu/Pharmacology/instruction/pha824mp/PHA824mp.html Buch, D.J.G., FAO in Pharmacology. 2009. Textbook of Receptor Pharmacology, ed. J.C. Foreman and T. Johansen. Vol. 20. 2003, CRC Press

intrinsic activity intrinsic activities receptor-mediated intrinsic activity full intrinsic activity

http://www.semanticweb.org/ontologies/2010/3/Ontology1271664172453.owl#activity