Link to this page
The Prescription of Drugs Ontology
Last uploaded:
September 4, 2020
Jump to:
| Id | http://purl.obolibrary.org/obo/CHEBI_8713
http://purl.obolibrary.org/obo/CHEBI_8713
|
|---|---|
| Preferred Name | quinapril |
| Definitions |
A member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure.
|
| Synonyms |
(3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
quinaprilum
quinapril
(3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
(3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Quinapril
|
| Type | http://www.w3.org/2002/07/owl#Class |
All Properties
| label |
quinapril
|
|---|---|
| prefLabel |
quinapril
|
| database_cross_reference |
LINCS:LSM-3620
Drug_Central:2340
Patent:US4344949
PMID:27165572
KEGG:C07398
Wikipedia:Quinapril
PMID:27169890
CAS:85441-61-8
KEGG:D03752
DrugBank:DB00881
PMID:29980144
PMID:17404826
See more
See less
|
| notation |
CHEBI:8713
|
| in_subset | |
| inchi |
InChI=1S/C25H30N2O5/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30)/t17-,21-,22-/m0/s1
|
| has_related_synonym |
(3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
quinaprilum
quinapril
|
| id |
CHEBI:8713
|
| charge |
0
|
| has_obo_namespace |
chebi_ontology
|
| prefixIRI |
CHEBI:8713
|
| textual definition |
A member of the class of isoquinolines that is (3S)-2-L-alanyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid in which the alpha-amino group of the alanyl residue has been substituted by a 1-ethoxycarbonyl-4-phenylbutan-2-yl group (the all-S isomer). A prodrug for quinaprilat (by hydrolysis of the ethyl ester to the corresponding carboxylic acid), it is used as an angiotensin-converting enzyme inhibitor (ACE inhibitor) used (generally as the hydrochloride salt) for the treatment of hypertension and congestive heart failure.
|
| formula |
C25H30N2O5
|
| subClassOf | |
| inchikey |
JSDRRTOADPPCHY-HSQYWUDLSA-N
|
| mass |
438.517
|
| monoisotopicmass |
438.21547
|
| is bearer of | |
| type | |
| smiles |
C1C2=C(C[C@H](N1C([C@@H](N[C@H](C(OCC)=O)CCC=3C=CC=CC3)C)=O)C(O)=O)C=CC=C2
|
| has_RxCUI |
35208
|
| has role | |
| has_exact_synonym |
(3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
(3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Quinapril
|
| bearer_of | |
| alternative term |
(3S)-2-{N-[(2S)-1-ethoxycarbonyl-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
quinaprilum
quinapril
(3S)-2-{(2S)-2-[(1S)-1-ethoxycarbonyl-3-phenylpropylamino]propanoyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
(3S)-2-{N-[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]-L-alanyl}-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
Quinapril
See more
See less
|
Add comment
| Delete | Subject | Author | Type | Created |
|---|---|---|---|---|
| No notes to display |