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The Prescription of Drugs Ontology
| Preferred Name | Nimodipine | |
| Synonyms |
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate nimodipinum 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester BAY e 9736 Nimotop Periplum nimodipine nimodipino 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nimodipine |
|
| Definitions |
A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm. |
|
| ID |
http://purl.obolibrary.org/obo/CHEBI_7575 |
|
| alternative term |
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate nimodipinum 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester BAY e 9736 Nimotop Periplum nimodipine nimodipino 2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nimodipine
|
|
| bearer_of |
http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_38215 |
|
| charge |
0
|
|
| database_cross_reference |
Drug_Central:1937 PMID:21869451 KEGG:C07267 PMID:22262041 CAS:66085-59-4 PMID:8519001 PMID:22300914 Reaxys:459792 PMID:12137606 Patent:DE2117571 PMID:17110283 LINCS:LSM-1659 Wikipedia:Nimodipine PMID:16180362 Patent:US3799934 DrugBank:DB00393 KEGG:D00438
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|
| formula |
C21H26N2O7
|
|
| has role |
http://purl.obolibrary.org/obo/CHEBI_35620 http://purl.obolibrary.org/obo/CHEBI_38215 |
|
| has_exact_synonym |
2-methoxyethyl propan-2-yl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Nimodipine
|
|
| has_obo_namespace |
chebi_ontology
|
|
| has_related_synonym |
isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-3,5-pyridinedicarboxylate isopropyl 2-methoxyethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate nimodipinum 2,6-dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-beta-methoxyethyl ester 5-isopropyl ester BAY e 9736 Nimotop Periplum nimodipine nimodipino
|
|
| has_RxCUI |
7426
|
|
| id |
CHEBI:7575
|
|
| in_subset | ||
| inchi |
InChI=1S/C21H26N2O7/c1-12(2)30-21(25)18-14(4)22-13(3)17(20(24)29-10-9-28-5)19(18)15-7-6-8-16(11-15)23(26)27/h6-8,11-12,19,22H,9-10H2,1-5H3
|
|
| inchikey |
UIAGMCDKSXEBJQ-UHFFFAOYSA-N
|
|
| is bearer of | ||
| label |
Nimodipine nimodipine
|
|
| mass |
418.44030
|
|
| monoisotopicmass |
418.17400
|
|
| notation |
CHEBI:7575
|
|
| prefixIRI |
CHEBI:7575
|
|
| prefLabel |
Nimodipine
|
|
| smiles |
COCCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC(C)C
|
|
| textual definition |
A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
|
|
| subClassOf |
http://purl.obolibrary.org/obo/CHEBI_50075 http://purl.obolibrary.org/obo/CHEBI_35725 http://purl.obolibrary.org/obo/CHEBI_51307 http://purl.obolibrary.org/obo/CHEBI_136838 |
| Delete | Subject | Author | Type | Created |
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