loading...| Preferred Name |
dornase alfa |
|
| Synonyms |
recombinanthuman deoxyribonuclease I |
|
| Definitions |
A recombinant human deoxyribonuclease I (rhDNAse) with selective DNA cleaving activity. Upon intrapleural administration, dornase alfa catalyzes the degradation of extracellular DNA in airway secretions, which can reduce their viscosity. Thus, dornase alfa may both promote the clearing of airway mucus and improve pulmonary function. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C81664" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C81664" NCI Thesaurus) |
|
| ID |
http://purl.bioontology.org/ontology/PDQ/CDR0000761150 |
|
| altLabel |
recombinanthuman deoxyribonuclease I recombinant human deoxyribonuclease I |
|
| CAS Registry |
143831-71-4 |
|
| cui |
C1135662 |
|
| DATE FIRST PUBLISHED |
2014-05-14 |
|
| Date last modified |
2014-05-14 |
|
| definition |
A recombinant human deoxyribonuclease I (rhDNAse) with selective DNA cleaving activity. Upon intrapleural administration, dornase alfa catalyzes the degradation of extracellular DNA in airway secretions, which can reduce their viscosity. Thus, dornase alfa may both promote the clearing of airway mucus and improve pulmonary function. Check for "https://www.cancer.gov/about-cancer/treatment/clinical-trials/intervention/C81664" active clinical trials using this agent. ("http://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI%20Thesaurus&code=C81664" NCI Thesaurus) |
|
| NCI ID |
C81664 |
|
| notation |
CDR0000761150 |
|
| ORIG STY |
Drug/agent |
|
| prefLabel |
dornase alfa |
|
| tui |
T116 T126 T121 |